Axonal Ephrin-As and Odorant Receptors
نویسندگان
چکیده
منابع مشابه
Axonal Ephrin-As and Odorant Receptors Coordinate Determination of the Olfactory Sensory Map
Olfactory sensory neurons expressing a given odorant receptor (OR) project with precision to specific glomeruli in the olfactory bulb, generating a topographic map. In this study, we demonstrate that neurons expressing different ORs express different levels of ephrin-A protein on their axons. Moreover, alterations in the level of ephrin-A alter the glomerular map. Deletion of the ephrin-A5 and ...
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Odorant receptors (ORs) control several aspects of cell fate in olfactory sensory neurons (OSNs), including singular gene choice and axonal identity. The mechanisms of OR-induced axon guidance have been suggested to principally rely on G-protein signalling. Here, we report that for a subset of OSNs, deleting G proteins or altering their levels of signalling does not affect axonal identity. Sign...
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The olfactory systems of various species solve the challenging problem of general molecular recognition in widely differing ways. Despite this variety, the molecular receptors are invariably G protein-coupled seven-transmembrane proteins, and are encoded by the largest gene families known to exist in a given animal genome. Receptor gene families have been identified in vertebrates and two inver...
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The Question The first time I thought about olfaction was when I read a 1985 paper from Sol Snyder's group that discussed the unsolved question of how odors are detected in the nose (Pevsner et al., 1985). This paper opened up a fascinating new world for me. It was estimated that humans could perceive 10,000 or more chemicals as having distinct odors. Even more remarkably, subtle changes in an ...
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ژورنال
عنوان ژورنال: Cell
سال: 2003
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(03)00568-3